Research activities, list of publications
Here is a complete list of my published articles in impact journals to date.
The latest publications are small additions to oncology and cardiology projects.
Another set of publications concerns proteomic research on neuroendocrine tumors pheochromocytomas and paragangliomas and the potential diagnostic or therapeutic targets found.
Previous work is methodologically focused, and concerns the development of a procedure for proteomic analysis focused on membrane proteins.
The oldest publications are on the resistance of human B lymphomas to a specific type of drug - nucleoside analogues.
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Daumova, L., Manakov, D., Petrak, J., Sovilj, D., Behounek, M., Andera, L., Vit, O., Souckova, O., Havranek, O., Dolnikova, A., Renesova, N., Tuskova, L., Winkowska, L., Bettazova, N., Kupcova, K., Kalbacova, M. H., Sikorova, M., Trneny, M., & Klener, P. (2025). Long-term adaptation of lymphoma cell lines to hypoxia is mediated by diverse molecular mechanisms that are targetable with specific inhibitors. Cell death discovery, 11(1), 65. https://doi.org/10.1038/s41420-025-02341-y
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Běhounek, M., Lipcseyová, D., Vít, O., Žáček, P., Talacko, P., Husková, Z., Kikerlová, S., Tykvartová, T., Wohlfahrt, P., Melenovský, V., Beneš, J., & Petrák, J. (2025). Biomarkers of RV Dysfunction in HFrEF Identified by Direct Tissue Proteomics: Extracellular Proteins Fibromodulin and Fibulin-5. Circulation. Heart failure, 18(3), e011984. https://doi.org/10.1161/CIRCHEARTFAILURE.124.011984
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Majtan, T., Olsen, T., Sokolova, J., Krijt, J., Křížková, M., Ida, T., Ditrói, T., Hansikova, H., Vit, O., Petrak, J., Kuchař, L., Kruger, W. D., Nagy, P., Akaike, T., & Kožich, V. (2024). Deciphering pathophysiological mechanisms underlying cystathionine beta-synthase-deficient homocystinuria using targeted metabolomics, liver proteomics, sphingolipidomics and analysis of mitochondrial function. Redox biology, 73, 103222. https://doi.org/10.1016/j.redox.2024.103222
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Vít, O., Talacko, P., Musil, Z., Hartmann, I., Pacák, K., & Petrák, J. (2023). Identification of Potential Molecular Targets for the Treatment of Cluster 1 Human Pheochromocytoma and Paraganglioma via Comprehensive Proteomic Characterization. Clinical Proteomics, 20(1), 39. https://doi.org/10.1186/s12014-023-09428-7
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Vít, O., & Petrák, J. (2023). Autotaxin and Lysophosphatidic Acid Signalling: The Pleiotropic Regulatory Network in Cancer. Folia biologica, 69(5-6), 149–162. https://doi.org/10.14712/fb2023069050149
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Vít, O., Patel, M., Musil, Z., Hartmann, I., Fryšák, Z., Miettinen, M., Pacák, K., & Petrák, J. (2021). Deep Membrane Proteome Profiling Reveals Overexpression of Prostate-Specific Membrane Antigen (PSMA) in High-Risk Human Paraganglioma and Pheochromocytoma, Suggesting New Theranostic Opportunity. Molecules (Basel, Switzerland), 26(21), 6567. https://doi.org/10.3390/molecules26216567
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Vít, O., Harant, K., Klener, P., Man, P., & Petrák, J. (2019). A Three-pronged "Pitchfork" Strategy Enables an Extensive Description of the Human Membrane Proteome and the Identification of Missing Proteins. Journal of Proteomics, 204, 103411. https://doi.org/10.1016/j.jprot.2019.103411
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Vít, O., & Petrák, J. (2017). Integral Membrane Proteins in Proteomics. How to Break Open the Black Box? Journal of Proteomics, 153, 8–20. https://doi.org/10.1016/j.jprot.2016.08.006
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Vít, O., Man, P., Kádek, A., Hausner, J., Sklenář, J., Harant, K., Novák, P., Ščigelová, M., Woffendin, G., & Petrák, J. (2016). Large-scale Identification of Membrane Proteins Based on Analysis of Trypsin-protected Transmembrane Segments. Journal of Proteomics, 149, 15–22. https://doi.org/10.1016/j.jprot.2016.03.016
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Toman, O., Kabíčková, T., Vít, O., Fišer, R., Poláková, K. M., Zach, J., Linhartová, J., Vyoral, D., & Petrák, J. (2016). Proteomic Analysis of Imatinib-resistant CML-T1 Cells Reveals Calcium Homeostasis as a Potential Therapeutic Target. Oncology Reports, 36(3), 1258–1268. https://doi.org/10.3892/or.2016.4945
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Lorková, L., Ščigelová, M., Arrey, T. N., Vít, O., Pospíšilová, J., Doktorová, E., Klánová, M., Alam, M., Vočková, P., Maswabi, B., Klener, P., Jr, & Petrák, J. (2015). Detailed Functional and Proteomic Characterization of Fludarabine Resistance in Mantle Cell Lymphoma Cells. PLoS One, 10(8), e0135314. https://doi.org/10.1371/journal.pone.0135314
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Klánová, M., Lorková, L., Vít, O., Maswabi, B., Molinský, J., Pospíšilová, J., Vočková, P., Mavis, C., Latečková, L., Kulvait, V., Vejmělková, D., Jakša, R., Hernandez, F., Trněný, M., Vokurka, M., Petrák, J., & Klener, P., Jr (2014). Downregulation of Deoxycytidine Kinase in Cytarabine-resistant Mantle Cell Lymphoma Cells Confers Cross-resistance to Nucleoside Analogs Gemcitabine, Fludarabine and Cladribine, but Not to Other Classes of Anti-lymphoma Agents. Molecular Cancer, 13, 159. https://doi.org/10.1186/1476-4598-13-159
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Pospíšilová, J., Vít, O., Lorková, L., Klánová, M., Živný, J., Klener, P., & Petrák, J. (2013). Resistance to TRAIL in Mantle Cell Lymphoma Cells is Associated With the Decreased Expression of Purine Metabolism Enzymes. International Journal of Molecular Medicine, 31(5), 1273–1279. https://doi.org/10.3892/ijmm.2013.1302
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Petrák, J., Pospíšilová, J., Šedinová, M., Jedelský, P., Lorková, L., Vít, O., Kolář, M., Strnad, H., Beneš, J., Sedmera, D., Červenka, L., & Melenovský, V. (2011). Proteomic and Transcriptomic Analysis of Heart Failure Due to Volume Overload in a Rat Aorto-caval Fistula Model Provides Support for New Potential Therapeutic Targets - Monoamine Oxidase a and Transglutaminase 2. Proteome Science, 9(1), 69. https://doi.org/10.1186/1477-5956-9-69
