Human IMPs

Imps

Web app integrating human proteome annotation data from Uniprot1 with the results of algorithms predicting transmembrane alpha helices (Phobius2, DeepTMHMM3, TOPCONS4, TMBED5).

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1 UniProt Consortium. UniProt: the Universal Protein Knowledgebase in 2025. Nucleic Acids Res. 2025;53(D1):D609-D617. doi:10.1093/nar/gkae1010

2 Käll L, Krogh A, Sonnhammer EL. A combined transmembrane topology and signal peptide prediction method. J Mol Biol. 2004;338(5):1027-1036. doi:10.1016/j.jmb.2004.03.016

3 Hallgren J, Tsirigos KD, Pedersen MD, Almagro Armenteros JJ, Marcatili P, Nielsen H, Krogh A, Winther O. DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks. bioRxiv 2022.04.08.487609. doi:10.1101/2022.04.08.487609

4 Tsirigos KD, Peters C, Shu N, Käll L, Elofsson A. The TOPCONS web server for consensus prediction of membrane protein topology and signal peptides. Nucleic Acids Res. 2015;43(W1):W401-W407. doi:10.1093/nar/gkv485

5 Bernhofer M, Rost B. TMbed: transmembrane proteins predicted through language model embeddings. BMC Bioinformatics. 2022;23(1):326. doi:10.1186/s12859-022-04873-x